实验室主页：http://159.226.149.45/other/labhuxintian/

学科带头人　胡新天　研究员　博士生导师

胡新天研究员生于1966年。1994年被美国普林斯顿大学心理系录取，师从著名神经科学家，美国科学院院士C. Gross 教授，进行灵长类认知神经科学的研究。其间，主要研究顶叶，前额叶在空间信息处理中的作用，他的部分博士研究结果曾发表在science 杂志上。2000年，获得了普林斯顿大学哲学博士学位后，到贝勒医学院做博士后，师从著名神经科学家Dave Sparks进行眼动的神经控制机制研究。2005年，入选中科院百人计划；同时，原来的导师Dave Sparks也受聘为动物所研究员，加盟动物所灵长类神经科学的研究。

研究方向

如果把脑看成一个信息处理系统，那么感觉是它的输入，而运动是它的输出。猕猴的眼睛运动控制系统具有负荷恒定（因为眼睛的重量在一定时间内是基本恒定的），行为简单（三维转动，易于精确测量），控制回路神经元容易记录以及它的控制中枢包括了低位脑干和高级皮层的特点。这些特点使得它成为脑功能研究中一个不可多得的系统。本实验室主要以猕猴眼动系统为模型，研究大脑的信息加工处理机制和可塑性。同时，因为眼睛运动控制牵涉到许多脑的高级功能，如注意，决策等，所以许多脑功能障碍，如精神分裂症，抑郁症等，都有相关的眼动异常。我们实验室也利用眼动为指标进行脑功能障碍早期诊断和机理方面的研究。

科研任务（2003-今）

研究团队（2003-今）——胡新天

发表论文

2008年发表论文

[1]Wang JH#, Zhang B^, Meng ZQ, Sun NL, Ma MX, Zhang HX, Wilson A.W. F., Hu XT*, Ma YY*: Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey. J of Neurobiology (In press).

2007年发表论文

[1]Xintian Hu#,，Huihui Jang, Chaoliang Gu, Chuanyu Li，David L. Sparks*: The Reliability of Oculomotor Command Signals Carried by Individual Neurons. PNAS 2007, 104: 8137－8142.

[2]Chaoliang Gu，Xintian Hu*，Shaowen Tian*，Peng Li, Bi Hu, Xinping Ouyang , Juan Fu, Jun Gao, Zeng Song, Li Han , Yuanye Ma*: Chronic Morphine Selectively Impairs Cued Fear Extinction in Rats: Implications for Anxiety Disorders Associated with Opiate Use Neuropsychopharmacology. (Accepted）

[3]Liu N, Li B, Sun NL, Hu XT*, Ma YY*: Effects of addiction associated and affective stimuli on the attentional blink in a sample of abstinent opiate dependent patients. Journal of Psychopharmacology（Accepted）　

2006年发表论文

[1]Ning Liu, Dongming Zhou, Bo Li, Yuanye Ma*, Xintian Hu*: Gender related effects of heroin abuse on the simple reaction time task. Addictive Behaviors 2006, 31: 187-190.

2005年发表论文

[1]Yanlin Lei, Tianyue Liu, Fraser A.W. Wilson, Dongming Zhoub,Yuanye Ma, Xintian Hu: Effects of extremely low-frequency electromagnetic fields on morphine-induced conditioned place preferences in rats. Neurosci Lett 2005 , 390: 72-75.

[2]Ning Liu, Yancheng Liu, Yaodong Fan, Hualin Yu, Fraser A.W. Wilson,c,Yuanye Ma*, Xintian Hu*: EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphinedependence, tolerance and withdrawal in rhesus monkeys. Brain Research 2005, 15053: 137-145.

[3]Sun N, Li Y, Tian S, Lei Y, Zheng J, Yang J, Sui N, Xu L, Pei G, Wilson FA, Ma Y*, Lei H, Hu X*: Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal. Neuroscience 2006, 138: 77-82.

[4]Ning Liu, Bo Li, Fraser A, W. Wilson, Yuanye Ma, Xintian Hu: Gender effect on the right-left discrimination task in a sample of heroin-dependent patients. Psychopharmacology 2005, 181: 735-740.

2005年以前发表论文

[1]Graziano, M. S. A., X. T. Hu & C. G. Gross: Coding the location of objects in the dark. Science 1997, 277: 239-242.

[2]Graziano, M. S. A., X. T. Hu, C. G. Gross: Visuospatial properties of ventral premotor. cortex J Neurophysiol 1997, 77: 2268-2292.

[3]Graziano, M. S. A., Alisharan SE, X Hu, C. G. Gross: The clothing effect: tactile neurons in the precentral gyrus do not respond to the touch of the familiar primate chair. Proc Natl Acad Sci 2002, 99: 11930-11933.

[4]Cai, Jingxia, Y.Y. Ma, L. Xu, X. T. Hu: Reserpine impairs spatial working memory performance in monkeys: reversal by the alpha-2 adrenergic agonist clonidine. Brain Res 1993, 614: 191-196.

[5]Cai, Jingxia, L. Xu, X.T. Hu, Y.Y. Ma, W. Su, K. Y Xiao: The relation between evolution of spatial working memory functionand of morphology of the dorsolateral prefrontal cortex among therhesus monkey, slow loris and tree shrew. Zoological research 1993, 14: 158-165.

[6]Li, Baoming, X. T. Hu, Z.T. Mei: Deficit of delayed go/no-go task performance induced by local injection of alpha-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in monkeys. Acta Psychologic Sinica 1992.

[7]Hu, X. T., Y. Y. Ma, L. Xu, J.X. Cai: The effects of acetylcholine (ach) applied iontophoretically on neurons of dorsalprefrontal cortex in the tree shrew. Primatology Today 1991, 383-384.

[8]Ma, Yuanye, X. T. Hu, L. Xu, K. Y Xiao: The influence of auditory, visual stimulation on the unit activity of dorsal prefrontal cortices in the tree shrew. Primatology Today 1991, 385-386.

[9]Ma, Yuanye, X. T. Hu, J. X. Cai, K. Y Xiao: The effects of acetylcholine (ach) on neurons sensitive to auditory and visual stimulation of dorsal prefrontal cortex in tree shrews. Primatology Today 1991, 387-388.

[10]Cai, Jingxia, Y.Y. Ma, X. T. Hu, L. Xu: Excitative and inhibitory effects clonidine-induced in the slow lores and rhesusmonkey. Primatology Today 1991, 387-388.

著书章节

　  胡新天，陈道奋。脑干的运动控制。神经生物学基础。主编：韩济生。（已完成）

　  Hu, X.T. & D.L. Sparks. Superior colliculus saccade related burst neurons. Encyclopedia Reference of Neuroscience, edited by U. Windhorst, M. Binder and N. Hirokawa. Publisher: Springer-Verlag (accepted).

Sparks, D.L. & Hu, X.T. Superior colliculus sensory map. Encyclopedia Reference of Neuroscience, edited by U. Windhorst, M. Binder and N. Hirokawa Publisher: Springer-Verlag (accepted).