实验室主页：http://159.226.149.45/mayuanye/

学科带头人　马原野　研究员　博士生导师

　　生于1955年。1987－1988年在美国耶鲁大学神经科学系做博士后研究，师从美国著名神经科学家Goldman-Rakic教授。该实验室主要进行大脑前额叶功能的电生理研究； 1995－1996年到英国牛津大学实验心理学系做访问科学家；1994年入选国家教委“优秀回国留学人员再出国”项目，到牛津大学著名神经心理学家D.Gaffan博士实验室进行灵长类前额叶的研究；1996－1999年在美国亚利桑那大学心理学系，进行"大脑认知地图"的研究；目前在国际脑研究组织，美国神经科学会，美国科学促进会等多个学术团体任职，并担任中国科学院心理研究所客座研究员。

研究方向

　　本学科组主要从事大脑前额叶认知功及其与某些精神、神经疾病关系以及心理成瘾的脑机制方面的研究。主要利用现代生物物理学、神经电生理学、神经行为学、神经药理学及生理心理学手段，探讨意识、认知过程的起源、演化及其脑机制。目前主要进行啮齿类和非人灵长类猕猴的大脑前额叶认知功能的研究，探讨其功能异常与某些精神、神经疾病等的关系以及药物成瘾心理戒断的脑机制。

我们的工作首先完善了在自由活动猕猴、大鼠脑上进行神经元单位放电活动记录的技术，并使得这项技术稳定，成熟，并在"脑认知地图"研究上得到很好的结果。其次我们在猕猴清醒状态、睡眠状态、麻醉状态等情况下，采用探测性诱发电位的方法，探讨了前额叶的功能，及多巴胺D2受体功能在其中的作用；建立了感觉阈值测定的方法，并在猕猴和大鼠吗啡依赖及戒断机制研究上取到很好的研究成果。我们还对戒断症状特异的敏感时期采用电生理技术，在猕猴和大鼠的海马、眶额叶等脑区进行了单位放电和脑电的记录，发现了与成瘾环境相关的特征单位放电及θ、γ频段

科研任务（2003-今）

研究团队（2003-今）

发表论文　　

2008年发表论文

[1]Wang JH#, Zhang B, Meng ZQ, Sun NL, Ma MX, Zhang HX, Wilson A.W. F., Hu XT*, Ma YY*: Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey. J of Neurobiology (In press).

[2]Wang JH#, Liu XF, Chen YM, Sun HY, Fu Y, Ma MX, He J, Wang HY, Wilson A.W. F., Ma YY*: Heroin impairs map/picture following and memory tasks dependent on gender and orientation of the tasks. Behavioral Neuroscience (In press).

[3]Ma MX, Chen YM, He J, Zeng T, Wang JH*: Effects of morphine and withdrawal on Y-maze spatial recognition memory in mice. Neuroscience (In press).

[4]Liu N, Li B, Sun N, Ma YY*: Effect of heroin abuse on the attentional blink. J Psychopharmacol (In press).

[5]Tan H, Liu N, Wilson FA, Ma Y: Effects of scopolamine on morphine induced reward-related learning and memory. Addict Biol (In press).

2006年发表论文

[1]Tan H, Meng Z, Liu N, Ma Y, Wilson FA: A Training Program for Visual Discrimination Tasks in Monkeys. Zoological Research 2006, 27: 601-605.

[2]Chen S, Liu N, Zheng JW, Qi H, Xiao Z: Auditory evoked potentials recorded in monkeys with hallucinatory-like behaviors induced by bromocriptine. Neuroscience Bulletin 2006, 22: 245-254.

[3]Wang JH#, Yang JZ, Wilson F, Ma YY*: Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring. Pharmacology Biochemistry and Behavior 2006, 84: 468-478.

[4]Wang JH, Ma YY, Buuse van den M: Improved spatial recognition memory in mice lacking the adenosine A2A receptors. Experimental Neurology 2006, 199: 438-45.　　

[5]Wang JH#, Fu Y, Wilson F, Ma YY*: Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice. Neuroscience 2006,140: 993-1002.

[6]Sun N, Li Y, Tian S, Lei Y, Zheng J, Yang J, Sui N, Xu L, Pei G, Wilson FA, Ma Y, Lei H, Hu X: Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal. Neuroscience 2006, 138: 77-82. 

[7]Tian S, Hu B, Li P, Zhao Z, Ouyang X, Zhou S, Ma Y: Assessing functioning of the prefrontal cortical subregions with auditory evoked potentials in sleep-wake cycle. Neurosci Lett 2006, 393: 7-11.

[8]Sun NL, Lei YL, Kim BH, Ryou JW, Ma YY, Wilson FA: Neurophysiological recordings in freely moving monkeys. Methods 2006, 38: 202-209.

[9]Liu N, Zhou D, Li B, Ma Y, Hu X: Gender related effects of heroin abuse on the simple reaction time task. Addict Behav 2006, 31:187-190.

[10]Xiang Y，Gao H，Zhu H，Sun N，Ma Y，Lei H. Neurochemical changes in brain induced by chronic morphine treatment: NMR studies in thalamus and somatosensory cortex of rats. Neurochem Res 2006, 31: 1255-1261.

2005年发表论文

[1]Lei Y, Liu T, Wilson FA, Zhou D, Ma Y, Hu X: Effects of extremely low-frequency electromagnetic fields on morphine-induced conditioned place preferences in rats. Neurosci Lett 2005, 390: 72-75.

[2]Liu N, Liu Y, Fan Y, Yu H, Wilson FA, Ma Y, Hu X: EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys. Brain Res 2005, 1053: 137-145.

[3]Wilson FA, Kim BH, Ryou JW, Ma YY: An automated food delivery system for behavioral and neurophysiological studies of learning and memory in freely moving monkeys. Behav Res Methods 2005, 37: 368-372.

[4]Liu N, Li B, Wilson FA, Ma Y, Hu X: Gender effect on the right-left discrimination task in a sample of heroin-dependent patients. Psychopharmacology (Berl) 2005, 181: 735-740.

[5]Jiawei Zheng, Yan Yang, Shaohua Tian, Jin Chen, Fraser A.W. Wilson, Yuanye Ma: The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats. Neurosci. Letters 2005, 82: 164-168.

[6]Liu N, Yu S, Zhou YF, Cai JX, Ma YY: Age-related effects of bromocriptine on sensory gating in rhesus monkeys. NeuroReport 2005, 16: 603-606.

[7]Che Y，Sun，H，Ma Y: The effect of prenatal morphine exposure on memory consolidation in the chick. Neuroscience Letters 2005, 380: 300-304.

[8]Wang Y, Zhou Y, Ma YY, Leventhal AG: Degradation of Signal Timing in Cortical Areas V1 and V2 of Senescent Monkeys. Cereb Cortex 2005 15: 403-408.

[9]Ingram N, Martin S, Wang JH, Laan S, Loiacono R, Buuse ven den M: Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice. Neuropharmacology 2005, 48: 80-92.

2004年发表论文

[1]Wilson FA, MA YY: Reinforcement-related neurons in the primate basal forebrain respond to the learned significance of task events rather than to the hedonic attributes of reward. Cogn Brain Res 2004, 19: 74-81.

[2]Wang JH, Cai JX , Ma YY: Effect of stress on memory process in a passive avoidance paradigm. Neurology Psychiatry and Brain Research 2004, 11: 103-108.

[3]Lei YL, Sun NL, Ma YY: Telemetric recordings of single neuron activity and visual scenes in monkeys walking in an open field. Journal of Neuroscience Methods 2004, 135: 35-41.

[4]Yu S, Liu Ning, Zeng Tao, Tian SH, Chen NH, Zhou YF, Ma YY: Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys. Neurosci Lett 2004, 366: 58-62.

[5]Buuse ven den M, Chavez C, Martin S, Wang JH: Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice. British J of Pharmacology 2004, 142: 543-550.

2003年发表论文

[1]Ma YY#, Tian BP, Wilson FA: Dissociation of egocentric and allocentric spatial processing in prefrontal cortex. Neuroreport 2003, 14: 1737-1741.

[2]Audie G. Leventhal, Yongchang Wang, Mingliang Pu, Yifeng Zhou, Ma YY: GABA and Its Agonists Improved Visual Cortical Function in Senescent Monkey. Science 2003, 300: 812-815.

[3]Wilson FA, Ma YY, Greenberg PA, Ryou JW, Kim BH: A microelectrode drive for long term recording of neurons in freely moving and chaired monkeys. J Neurosci Methods 2003, 127: 49-61.

[4]Wang JH, Ma YY: Effect of paradoxical sleep deprivation and stress on passive avoidance. Physiology and Behavior 2003, 79: 516-519.

[5]Ma YY，Ryou JW, Kim BH and Wilson FA: Spatially-directed movement and neuronal activity in freely moving monkeys. In: Mori S, Stuart DG, Wiesendanger M, editors. Brain Mechanisms for the Integration of Posture and Movement, Progress in Brain Research, chapter 48. Amsterdam: Elsevier, 2003：505-512。

2003年以前发表论文

[1]Tian SW，Ma YY: Differential amplitude modulation of auditory evoked cortical potentials associated with brain state in the freely moving rhesus monkey. Neurosci Lett 2002, 331: 159-162.

[2]Gutnikov SA, Ma YY, Buckley MJ, Gaffan D: Monkeys can associate visual stimuli with reward delayed by 1 second even after perirhinal cortex　 ablation ,uncinate fascicle section or amygdalectomy. Behav Brain Res 1997, 87: 85-96.

[3]Gutnikov S.A., Ma YY, Gaffan D: Temporo-frontal disconnection impairs visual paired association learning but not visual configural learning in macaca monkeys. Eur J Neurosci 1997 9: 1524-1539.

[4]Cai jX, Ma YY, Xu L, Hu XT: Reserpine impairs spatial working memory performance in monkeys: reversal by adrenergic agonist clonidine. Brain Res 1993, 614: 191-196.

[5]Pu XC, Ma YY, Cai JX: A Study on the effect of lesions of area 7 of the parietal cortex on the short-term visual spatial memory of rhesus monkeys. Brain Res 1993, 600: 187-192.

[6]Liu SQ, Wu J, Yang JZ, Tian SH, Chen NH, Lei YL, Peng YP, Wang JH, Ma YY: Methods for single unit recording in behavioring morphine craving rat. Sheng Li Xue Bao 2004, 56: 735-742.

著作

　　马原野，王建红主编。《认知神经科学原理和方法》，重庆出版社。2003。字数：66万字。

　　马原野。《遗传脑，环境脑，意识脑》，山西科技出版社。在编。字数：约25万字。

书稿章节

　　马原野。人类智能。《人与智能》，彩图科技百科全书，第四卷。上海科学技术出版社，上海科技教育出版社，张存浩，陈竺主编。2005：4-5。

　　马原野。大脑前额叶皮层在自我意识中的作用。《意识与大脑》汪云九，杨玉芳等主编。人民出版社，2003：98-114。

　　马原野。有机体信息系统的演化在物种生存,适应过程中的作用《21世纪100个科学难题》中国科学院21世纪100个科学难题编写组主编，吉林人民出版社，1998，489-497。

　　马原野。认知进化过程中的若干问题《21世纪初科学发展趋势》21世纪初科学发展趋势课题组主编科学出版社，1996，326-327。

　　马原野。叶猴神经生物学，《叶猴生物学》，叶智彰主编 1993，427-449 云南科技出版社。

　　马原野。树鼩神经生物学，《树鼩生物学》，彭燕章主编，1991，云南科学技术出版社。

　　马原野，蔡景霞。树鼩, 懒猴脑与行为的比较研究，《神经科学前沿》，冯德培, 张香桐, 邹冈主编，知识出版社，1986，355-370。

申请专利

[1] 马原野，缪应达，王建红，汪茂华，肖昆媛，蔡景霞。猕猴大脑神经元多单位电活动室外记录系统。专利号：ZL00105039.7

[2] 王建红，田绍文，杨建珍，齐华，马原野，蔡景霞水迷宫大鼠脑内记录神经元放电装置。专利号：ZL00105040.0

[3] 曾涛等。自由活动实验动物运动、行为和生理指标检测分析系统。

[4] 曾涛等。实验动物行为和电生理信号同步记录系统。申请号：200310111149.9

[5] 陈南晖等。人工智能脑电采集和分离系统。申请号：200310111150.1