|  PI简介
季维智，中科院昆明动物研究所研究员，博士研究生导师。1996-2005年任中科院昆明动物研究所所长，现为中科院昆明灵长类中心主任。1985-1987年赴美国俄勒岗灵长类研究中心和华盛顿史密研究院从事神经生殖内分泌和胚胎移殖研究。1995-1997年为美国威斯康星大学，动物医学与生物化学系客座教授。1996年与威斯康星灵长类研究中心在昆明动物研究所共建了中——美灵长类生物学联合实验室，为该实验室中方主任。
多年来一直从事灵长类生殖发育生物学研究，率先在国内开展灵长类干细胞研究。建立了包括人、猕猴、兔和小鼠的胚胎干细胞系和多株成体干细胞系，研究发现胚胎干细胞向神经干细胞分化的机制及体内整合机制问题，获得98%分化效率；目前在干细胞的自我更新机制和干细胞替代治疗研究方面已获得重要进展。在本领域高水平的杂志，如“Stem Cells”，“Biology of Reproduction”，“Human Reproduction”等杂志上发表论文80余篇。
2、实验室研究方向介绍：
胚胎干细胞的定向分化的机制
动物克隆和移植核再程序化的机制
细胞再程序化和诱导多功能干细胞
配子形成与受精的机制
动物种质资源的冷冻保存
3、在研项目
中国科学院重点资助项目
国家重点基础研究发展计划(973)项目
国家自然科学基金资助项目
4、实验室成员
和协超 5198996
纪少珲 5190590
牛昱宇 5190490
司维 5190490
唐向辉 5198996
谢云华 5198996
谭韬 5198996
郭祥玉 5198996
陈永昌 5198996
魏强 5198996
王喜宏 5198996
柏春玲 5198996
卢斌 5198996
谢正媛 5198996
赵博 5198996
5、近5年发表的代表性文章：
1. Yang S, He X, Niu Y, Wang X, Lu B, Hildebrandt TB, Goeritz F, Jewgenow K, Zhou Q, Ji W. 2009 Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys. Theriogenology. 72:560-565.
2. Yang S, He X, Niu Y, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Chang Y, Zhou Q, Ji W. 2009 Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys. Theriogenology. 72:243-250.
3. Wang S, Shen Y, Yuan X, Chen K, Guo X, Chen Y, Niu Y, Li J, Xu RH, Yan X, Zhou Q, Ji W. 2008 Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells. J Biol Chem. 283:35929-35940.
4. Yang S, Shen Y, Niu Y, Hildebrandt TB, Jewgenow K, Goeritz F, He X, Zhou Q, Ji W. 2008 Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season. Theriogenology. 70:108-114.
5. Niu Y, Yang S, Ding C, Yang J, He X, Xie Y, Tang X, Zhou Q, Ji W 2008. Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos. Cloning Stem Cells.10: 25-36.
6. Yang S, He X, Hildebrandt TB, Zhou Q, Ji W. 2007 Superovulatory response to a low dose single-daily treatment of rhFSH dissolved in polyvinylpyrrolidone in rhesus monkeys. Am J Primatol. 69:1278-1284.
7. Yang S, He X, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Zhou Q, Ji W. 2007 Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys. Theriogenology. 67:1194-1201.
8. Wang SF, Tang XH, Niu YY, Chen HW, Li B, Li TQ, Zhang XZ, Zhou Q, Ji WZ. 2007 Generation and characterization of rabbit embryonic stem cells. Stem Cells. 25:481-489
9. Niu Y, Greube A, Ji W, Jewgenow K 2006 The application of in vitro sperm competition test to evaluate the impact of ZP-derived peptides on fertilization capacity of cat sperm. Theriogenology 66:989-995.
10. Yang J, Yang S, Beaujean N, Niu Y, He X, Xie Y, Tang X, Wang L, Zhou Q, Ji WZ. 2007 Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biol Reprod. 76:36-42
11. Zhou Q, Yang SH, Ding CH, He XC, Xie YH, Hildebrandt TB , Niu YY, Mitalipov SM, Tang XH, Wang L, Wolf DP, Ji WZ. 2006 Comparative approach to somatic cell nuclear transfer in the rhesus monkey. Human Reproduction. 21:2564-2571.
12. Li Y, Cai K, Li J, Dinnyes A, Ji W. 2006 Comparative studies with six extenders for sperm cryopreservation in the cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta). Am J Primatol. 68:39-49.
13. Si W, Wang H, Reid C, Hildebrandt TB, Ji W. 2006 Effect of sugar type on the survival of frozen-thawed rhesus monkey (Macaca mulatta) sperm. Am J Primatol. 68:103-108.
14. Si W, Hildebrandt TB, Reid C, Krieg R, Ji W, Fassbender M, Hermes R. 2006 The successful double cryopreservation of rabbit (Oryctolagus cuniculus) semen in large volume using the directional freezing technique with reduced concentration of cryoprotectant. Theriogenology. 65:788-798.
15. Li TQ, Zheng JW, Xie YH, Wang SF, Zhang XZ，Li J, JinLF, MaYY Wolf DP, Zhou Q, JiWZ. 2005 Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. Stem Cells. 23: 1295-1303.
16. Li TQ, Wang SF, Zheng JW, Xie YH, Lu YQ, Zhang XZ，Wolf DP, Zhou Q,JiWZ. 2005 Homologous feeder cells support undifferentiated growth and pluripotency in monkey embryonic stem cells. Stem Cells. 23: 1192-1199
17. Cai K, Yang J, Guan M, Ji W, Li Y, Rens W. 2005 Single UV excitation of Hoechst 33342 and propidium iodide for viability assessment of rhesus monkey spermatozoa using flow cytometry. Arch Androl. 51:371-383.
18. Li YH, Cai KJ, Su L, Guan M,He XC, Wang H,Kovacs A, Ji WZ. 2005 Cryopreservation cynomolgus monkey (Macaca fascicularis) spematozoa in camical defined exteder. Asian J Androl. 7: 139–144
19. Li YH, Cai KJ, Kovacs A, Ji WZ. 2005 Effects of Various Extenders and Permeating Cryoprotectants on Cryopreservation of Cynomolgus Monkey (Macaca fascicularis) Spermatozoa. J Androl. 26: 387-395.
20. Si W, Zheng P, Li Y, Dinnyes A, Ji W. 2004 Effect of glycerol and dimethyl sulfoxide on cryopreservation of rhesus monkey (Macaca mulatta) sperm. Am J Primatol. 62:301-306.
6、获奖情况
2001年云南省科学技术奖（自然科学类）一等奖
2004年云南省科学技术奖（科技进步类）三等奖
2008年云南省科学技术奖（自然科学类）二等奖
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