| 论文题目: | Brain Developmental and Cortical Connectivity Changes in the Transgenic Monkeys Carrying the Human-specific Duplicated Gene srGAP2C |
| 作者: | Xiaoyu Meng, Qiang Lin, Xuerui Zeng, Jin Jiang, Min Li, Xin Luo, Kaimin Chen, Haixu Wu, Yan Hu, Cirong Liu, Bing Su |
| 联系作者: | sub@mail.kiz.ac.cn |
| 发表年度: | 2023 |
| DOI: | |
| 摘要: | The human-specific duplicated genes contribute to phenotypic innovations during the origin of our own species, such as the enlarged brain and highly developed cognitive abilities. While prior studies on transgenic mice carrying the human-specific srGAP2C gene have shown enhanced brain connectivity, the relevance to humans remains unclear due to the significant evolutionary gap between humans and rodents. In this study, to investigate the phenotypic outcome and the underlying genetic mechanism of srGAP2C, we generated transgenic cynomolgus macaques (Macaca fascicularis) carrying the human-specific srGAP2C gene. Longitudinal MRI imaging revealed delayed brain development with region-specific volume changes, accompanied by altered myelination levels in the temporal and occipital regions. On a cellular level, the transgenic monkeys exhibited increased deep-layer neurons during fetal neurogenesis and delayed synaptic maturation in adolescence. Moreover, transcriptome analysis detected neotenic expression in molecular pathways related to neuron ensheathment, synaptic connections, extracellular matrix, and energy metabolism. Cognitively, the transgenic monkeys demonstrated improved motor planning and execution skills. Together, our findings provide new insights into the mechanisms of how the newly evolved gene shapes up the unique development and circuitry of the human brain |
| 刊物名称: | National Science Review |
| 论文出处: | https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwad281/7342471?login=true |
| 影响因子: | 20.7(2022IF) |
