报告题目：Role of impaired hepatocyte growth hormone signaling in the etiology of non-alcoholic fatty liver disease
报 告 人：Rhonda D. Kineman, Associate Professor, University of Illinois at Chicago
Rhonda D. Kineman
Associate Professor at the University of Illinois at Chicago, Dept of Medicine, Section of Endocrinology, Diabetes and Metabolism. E-mail: KINEMAN@uic.edu
Her research interests include how growth hormone (GH) directly regulates hepatocyte metabolism, injury and repair in adults. Current projects include how GH interacts with insulin to regulate hepatic lipid and carbohydrate metabolism, as well as studies examining the direct effects of GH on pancreatic beta-cell function. They are also interested in how changes in the metabolic environment alter GH production and sensitivity.
Up yet, her team has published more than 100 papers on the well known professional journals including Endocrinology, Diabetes, Oncogene and so on.
1. Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S. Growth Hormone Control of Hepatic Lipid Metabolism. Diabetes 2016, 65(12):3598
2. Kineman RD, Majumdar N, Subbaiah PV, Cordoba-Chacon J. Hepatic PPAR is not essential for the rapid development of steatosis following loss of hepatic GH signaling, in adult male mice. Endocrinology 2016, 157(5): 1728-1735.
3. Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A., Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD. Growth hormone inhibits hepatic de novo lipogenesis in adult mice. Diabetes 2015, 64(9):3093-103.
4. Luque RM, Ibáñez-Costa A, Vieira Neto L, Taboada GF, Hormaechea-Agulla D, Kasuki L, Venegas-Moreno E, Moreno-Carazo A, Ángeles Gálvez M, Soto-Moreno A, Kineman RD, Culler MD, Gahete MD, Gadelha MR, Castaño JP. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. Cancer Letters 2015, 359(2):299-306.