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学术报告(10月18日上午)
2017-10-10 | 作者: | 来源:神经发育与进化研究组 | 【小  大】【打印】【关闭】

  报告题目:Novel regulators of Wnt-LRP6 signaling involved in embryonic development 

  报告人: Prof. Dr. Christof Niehrs 

  Institute of Molecular Biology,Mainz,Germany 

  时间:2017年10月18日(星期三)上午10 :30 

  地点:西南生物多样性实验室1-24-26会议室 

  报告人简介 : 

  Prof. Dr. Christof Niehrs 

  Institute of Molecular Biology (IMB), Mainz,Germany 

  Positions held 

  · 2010 - 2015: 

  Executive Director, Institute of Molecular Biology (IMB), Mainz

  · Since 2010: 

  Founding & Scientific Director, IMB, Mainz

  Professor, Faculty of Biology, Johannes Gutenberg University Mainz (JGU)

  · Since 2000: 

  Professor of Molecular Embryology, German Cancer Research Center (DKFZ), Heidelberg

  · Since 1994: 

  Head of Division "Molecular Embryology", DKFZ, Heidelberg

  · 1990 - 1993: 

  Postdoc, University of California, Los Angeles (UCLA)

  Education 

  · 1997: 

  Habilitation in Biology, University of Heidelberg

  · 1990: 

  PhD in Biology, European Molecular Biology Laboratory (EMBL) and University of Heidelberg

  · 1985: 

  Diploma in Biochemistry, Free University of Berlin

  Research interest: Roles and regulation of Wnt signaling; DNA demethylation, DNA repair and reprogramming. 

  Representative Publications: 

  1. Schomacher L. et al. (2016). Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.Nat Struct Mol Biol. 23(2):116-124. 

  2. Koch S. et al. (2015). Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.Cell. 163(5):1225-1236. 

  3. Huang Y.L., et al. (2014). Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.Proc Natl Acad Sci U S A. 112(18):5732-7. 

  4. Acebron S.P. et al. (2014). Mitotic wnt signaling promotes protein stabilization and regulates cell size.Mol Cell54(4):663-74. 

  5. Huang Y.L., Niehrs C. (2014). Polarized Wnt signaling regulates ectodermal cell fate in Xenopus.Dev Cell. 29(2):250-7. 

  6. Cruciat C.M. et al. (2013). RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.Science. 339(612-6):1436-41. 

  7. Schäfer A. et al. (2013). Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.Genes Dev. 27(3):261-73. 

  8. Gierl M.S. et al. (2012).GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.Dev Cell.23(5):1032-42. 

  9. Cruciat C.M. (2010), Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science. 327(5964):459-63. 

  10. Bilic J. et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.Science. 316(5831):1619-22. 

  11. Barreto G et al. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.Nature.445(7128):671-5. 

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