中国科学院昆明动物研究所研究员，博士生导师。致力于人类神经系统疾病的遗传机制解析。 在Cell、Nature Aging、Nature Communications、Neuron、PNAS、Cell Research等SCI期刊发表多篇研究论文。现任动物学领域知名SCI期刊 Zoological Research 青年编委。

工作与教育经历

2025. 07- 现在  中国科学院昆明动物研究所，脑疾病遗传与机理学科组带头人

2022. 06 - 2025. 07   美国国家健康研究院国家神经疾病与中风研究所(National Institute of Neurological Disorders and Diseases, National Institutes of Health)，Research Fellow

2020. 08 - 2022. 06   美国国家健康研究院国家神经疾病与中风研究所(National Institute of Neurological Disorders and Diseases, National Institutes of Health)，Visiting Fellow

2017. 06 - 2020. 07  美国国家健康研究院国家癌症研究所(National Cancer Institute, National Institutes of Health)，Visiting Fellow

2016. 07 - 2017. 02   杜克大学-新加坡国立大学医学院 (Duke-MUS Medical School), Research Fellow

2012. 09 - 2016. 07    中国科学院遗传与发育生物学研究所，获博士学位

2009. 09 - 2012. 03    上海交通大学，生物工程系，获硕士学位

2005. 09 - 2009. 07    海南大学，生物技术系，获学士学位

方向一

神经递质失衡诱发神经系统相关疾病，主要研究成瘾相关的神经系统疾病的遗传基础和分子机制解析，试图寻找关键靶点对疾病进行干预。

方向二

依托模式动物表型与遗传研究国家重大科技基础设施（灵长类设施）国家级大平台，创建外界环境因素诱导和遗传修饰的神经系统疾病动物模型，研究相关疾病的发病机制。

2021 NIH FARE Award

2020 NIH FARE Award

2016 中国科学院院长优秀奖、中国科学院优秀毕业生，北京市优秀毕业生，

2012 上海交通大学优秀毕业生

1. 云南省“兴滇英才支持计划” 项目，2025.01-2028.12， 在研 主持；

近5年内发表的代表性论文/专著

Wang G,Peng S, Reyes Mendez M, Keramidas A, Castellano D, Wu K, Han W, Tian Q, Dong L, Li Y, Lu W. The TMEM132B-GABAA receptor complex controls alcohol actions in the brain. Cell. 2024, 187:6649-6668.

Wang G, Yin W, Shin H, Tian Q, Lu W, Hou SX. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nature Aging. 2021. 1:1024–1037.

Wang G*, Jin S*, Liu J, Li X, Dai P, Wang Y, Hou SX. A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice. Natl Sci Rev. 2023 10(12):nwad222. (co-first author)

Wang G, Xu J, Zhao J, Yin W, Liu D, Chen W, Hou SX. Arf1 Ablation Kills Cancer Stem Cells and Induces DAMP-mediated Anti-tumor Immune Responses in Mice.Nature Communications.2020, 11: 220.

Wang Y, Li Q, Ding Y, Luo C, Yang J, Wang N, Jiang N, Yao T, Wang G, Shi G, Hou SX. Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti-Tumor Immunity. Adv Sci. 2024, 11(39):e2404442.

其他代表性论文/专著

Wang G, Liu X, Gaertig MA, Li S, Li XJ. Ablation of huntingtin in adult neurons is non-deleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A. 2016, 113(12):3359-3364.

Wang G*, Yang H*, Yan S*, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, Lai L. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Mol Neurodegener. 2015, 10:42. (Co-first author)

Chen R, Qiao S, Wang H, Liu Y, Wang Z, Wang G^#, Shang P^#. Editorial: Lifestyle and environmental influences on Alzheimer's disease: exploring the roles of diet, exercise, cognitive reserve, sleep, and air quality. Front. Aging Neurosci. 2025, 17: doi.org/10.3389/fnagi.2025.1657074 (co-corresponding)

Pandey S, Ostergren S, Li J, Peng S, Wang G, Tian Q, Dong L, Lu W. A critical role of Neuroligin 2 C-terminus in OCD and social behavior. J Neurosci. 2025, 45(19):e1417242025.

Wang G^#, Yin P, Zhang W, Giulietta Fernandez C, Xu X^#. Editorial: The relationship of neuroinflammation with aging and neurodegenerative diseases.Front Aging Neurosci. 2022, 14:1102613. (co-corresponding)

Yang W*, Wang G*, Wang CE*, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-Synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015, 35(21):8345-8358. (Co-first author)

Huang B, Wei W, Wang G, Gaertig MA, Feng Y, Wang W, Li XJ, Li S. Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 2015, 85(6):1212-1226.

Yang H*, Wang G*, Sun H*, Shu R*, Liu T, Wang CE, Liu Z, Zhao Y, Zhao B, Ouyang Z, Yang D, Huang J, Zhou Y, Li S, Jiang X, Xiao Z, Li XJ, Lai L. Species-dependent neuropathology in transgenic SOD1 pigs. Cell Res. 2014, 24(4):464-481. (Co-first author)

Wang G* Huang X* Li S, Huang J, Wei X, Li Y, Xu Y. The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. J Bacterial. 2012, 194(10):2443-2457. (Co-first author)

Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ. N-terminal huntingtin knock-in mice: Implications of removing the N-terminal region of huntingtin for therapy. PLoS Genet. 2016, 12(5): e1006083.