赵博，中国科学院昆明动物所研究员，基因组稳定调控学科组负责人。利用干细胞和新型类器官技术体系，研究环境因素（低氧、环境新污染物等）对心脏、脑、血管和生殖等重要器官的影响，旨在揭示遗传-环境交互调节组织器官稳态的机制，为环境健康基础研究和产业发展提供了新的驱动力。获中国科学院海外引进高层次人才、云南省“兴滇英才”、昆明市春城计划等人才项目资助，主持科技部重点研发计划发育编程及其代谢调节专项（子课题负责人）、常见多发病防治专项（课题骨干）。现任Zoological Research、The Innovation、Genome Instability & Disease等期刊青年编委。在Cell Stem Cell、Cell Research、Nature Communications、Science Advances、Cellular and Molecular Life Sciences、Journal of Experimental & Clinical Cancer Research等期刊发表论文。

经历

2003.09 - 2007.06   烟台大学 生命科学学院，获理学学士学位

2007.09 - 2013.07   中国科学院昆明动物研究所，获理学博士学位

2013.08 - 2015.12   中国科学院昆明动物研究所，助理研究员

2016.01 - 2017.05   中国科学院昆明动物研究所，副研究员

2017.06 - 2020.07   Wistar Institute 美国费城，博士后

2020.09 - 至今      中国科学院昆明动物研究所，研究员 博士生导师

方向一

干细胞和类器官技术。利用人源多能干细胞开发心脏类器官、微血管类器官、脑类器官（类脑）等构建培养体系，结合微流控芯片技术实现类器官的规模化制备、高通量连续动态监测和表型评价。

方向二

环境新污染物的毒理效应。利用心脑血管类器官平台和小鼠、非人灵长类等活体动物模型，着重研究新污染物对器官发育和稳态的影响，以及对生殖遗传的分子毒理机制。

方向三

低氧对器官发育和功能的影响。利用心脑血管类器官模型，着重研究低氧驱动的基因表达和细胞重塑、基因组稳定性（DNA复制、DNA修复）和变异规律等。

Zoological Research, The Innovation, Genome Instability & Disease期刊青年编委

2016年：中国科学院青年创新促进会会员

2016年：国际干细胞学会（ISSCR）年会旅行奖，美国旧金山

2015年：国际干细胞学会（ISSCR）年会旅行奖，瑞典斯德哥尔摩

2015年：云南省科研机构联合会，年度优秀论文奖

1. 科技部重点研发计划“发育编程及其代谢调节”项目子课题，主持

2. 科技部重点研发计划“常见多发病防治”项目子课题，骨干

近5年内发表的代表性论文/专著

1. Qiu Tu^#, Xiuyun Liu^#, Xiaoqing Yao^#, Ruixue Li^#, Gaojing Liu^#, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu*, Hong Zhu*, Peng Shi*, Bo Zhao*. RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma. Journal of Experimental & Clinical Cancer Research. Sep 15;41(1):274. 2022.

2. Kaiqin Li^#, Gaojing Liu^#, Xiuyun Liu^#, Qiongfang Chen^#, Xiaoyan Huang^#, Qiu Tu, Jiao Zhang, Qing Chang, Yunhua Xie, Rong Hua, Dongming Xu, Zhen Liu, Bo Zhao*. EPAS1 prevents telomeric damage induced senescence through enhancing transcription of TRF1, TRF2 and RAD50. Zoological Research, May 18;44(3):636-649. 2023

3. Weidao Zhang, Min Tang, Lin Wang, Ping Zheng*, Bo Zhao*. Purification of Long Non-coding RNAs on Replication Forks Using iROND (Isolate RNAs on Nascent DNA). Bio Protocol, Nov 5;13(21):e4869. 2023

4. Wanzhi Cai^#, Xiaoqing Yao^#, Gaojing Liu, Xiuyun Liu, Bo Zhao*, Peng Shi*. RetSat stabilizes mitotic chromosome segregation in pluripotent stem cells. Cellular and Molecular Life Sciences, Aug 22;81(1):366. 2024

5. Qiu Tu, Gaojing Liu, Xiuyun Liu, Jiao Zhang, Wenxian Xiao, Longbao Lv*, Bo Zhao*. Perspective on using non-human primates in Exposome research. Ecotoxicology and Environmental Safety. Nov 1:286:117199. 2024

其他代表性论文/专著

1. Bo Zhao, Wei-dao Zhang, Ying-liang Duan, Yong-qing Lu, Yi-xian Cun, Chao-hui Li, Kun Guo, Wen-hui Nie, Lei Li, Rugang Zhang, Ping Zheng*. Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability. Cell Stem Cell, 16: 684-98. 2015.

2. Bo Zhao^#, Weidao Zhang^#, Yixian Cun, Jingzheng Li, Yan Liu, Jing Gao, Hongwen Zhu, Hu Zhou, Rugang Zhang, Ping Zheng*. Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex. Cell Research, 28: 69-89. 2018.

3. Bo Zhao, Jianhuang Lin, Lijie Rong, Shuai Wu, Zhong Deng, Nail Fatkhutdinov, Joseph Zundell, Takeshi Fukumoto, Qin Liu, Andrew Kossenkov, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Ronny Drapkin, Paul M. Lieberman, Cory T. Abate-Shen, Rugang Zhang*. ARID1A promotes genomic stability through protecting telomere cohesion. Nature Communications. Sep 6;10(1):4067. 2019.

4. Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang*. Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence. Nature Communications. Feb 19;11(1):908. 2020.

5. Xue Hao^#; Bo Zhao^#; Wei Zhou; Heng Liu; Takeshi Fukumoto; Dmitry Gabrilovich; Rugang Zhang*; Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype. iScience. 24(1): 102016. 2021.