蔡欣，理学博士，副研究员。主持NSFC青年科学基金项目、云南省应用基础研究计划面上项目、中国科学院特别研究助理项目，入选云南省兴滇英才计划。在Science Advances、Nature Communications、Biological Psychiatry、Molecular Psychiatry等期刊发表多篇论文。

学习和工作经历

2024.02 – 至今，中国科学院昆明动物研究所，副研究员

2023.07 – 2024.01，中国科学院昆明动物研究所，助理研究员

2017.09 – 2023.06，中国科学院大学，神经生物学，博士

2013.09 – 2017.06，苏州大学，生物技术（免疫工程），学士

研究方向一：精神分裂症及双相障碍的致病机制解析

利用原代神经元培养、基因操控小鼠模型及遗传变异（单碱基和串联重复片段）精准编辑等技术，探究遗传因素究竟如何在分子、细胞、生理及行为层面介导疾病发生发展，揭示疾病表型与遗传风险间的因果关系。

研究方向二：药物作用机制解析与新药靶点挖掘

基于iPSC重编程、人源类器官诱导分化及疾病动物模型，系统研究现有药物的作用机制，揭示临床上产生不同药物反应的分子基础，为寻找新的药物靶点提供线索。

国家自然科学基金青年项目，2025 – 2027，主持

中国科学院特别研究助理项目，2024 – 2025，主持

云南省基础研究专项-面上项目，2024 – 2027，主持

中国科学院稳定支持基础研究领域青年团队计划，2026 – 2030，参与

近5年内发表的代表性论文/专著

(1)  Cai X.^#, Yang Z. H.^#, Li H. J., Xiao X., Li M.*, Chang H.*. (2021). A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT^d2d3 and Mushroom Dendritic Spine Density. Schizophrenia Bulletin, 47(1), 219-227.

(2)  Zhou D. Y.^#, Zhang Y. ^#, Yang Z. H.^#, Zhang C. Y., Zhang Q., Huo J. H., Cui K. S., Wu Y., Chang H., Wang C., Xiao X.*, Cai X.*, Li M.*. (2026) A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia. Science Advances, 2026, 12(3), eadw7667.

(3)  Yang Z. H.^#, Cai X.^#, Zhang C. Y., Zhang Q., Li M., Ding Z. L., Guo Y. Q, Ma G. L, Yang C. H., Guo L., Chang H., Wang C., Li M.*, Xiao X.* (2024) NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Nature Communications, 2024, 15(1), 9180.

(4)  Zhang C. Y.^#, Cai X.^#, Guo L., Wang L., Liu Z., Luo X.-J., Li M., Dou Z., Guan S., Guo T., Liu Q., Lo H., Zhang L., Gese D. N. A. R. T, Wang C.*, Li T.*, Xiao X.*. (2023). Genetic evidence for the “dopamine hypothesis of bipolar disorder”. Molecular Psychiatry, 28(2), 532-535.

(5)  Yang Z. H.^#, Cai X.^#, Ding Z. L.^#, Li W.^#, Zhang C. Y., Huo J. H., Zhang Y., Wang L., Zhang L. M., Li S. W., Li M., Zhang C.*, Chang H.*, Xiao X.*. (2023) Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. BMC Medicine, 2023, 21(1): 254.

(6)  Chen R.^#, Yang Z. H.^#, Liu J. W.^#, Cai X.^#, Huo Y. X., Zhang Z. J., Li M.*, Chang H.*, & Luo X. J.*. (2022). Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants. Genome Medicine, 14(1), 53.

(7)  Chang H.^#, Cai X.^#, Li H. J.^#, Liu W. P., Zhao L. J., Zhang C. Y., Wang J. Y., Liu J. W., Ma X. L., Wang L., Yao Y. G., Luo X. J., Li M.*, Xiao X.*. (2021). Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus. Biological Psychiatry, 89(3), 246-255.

(8)  Li W. Q.^#, Cai X.^#, Li H. J.^#, Song M.^#, Zhang C. Y., Yang Y. F., Zhang L. W., Zhao L. J., Liu W. P., Wang L., Shao M. L., Zhang Y., Zhang C., Cai J., Zhou D. S., Li X. X., Hui L., Jia Q. F., Qu N., Zhong B. L., Zhang S. F., Chen J., Xia B., Li Y., Song X. Q., Fan W. X., Tang W., Tang W. X., Tang J. S., Chen X. G., Yue W. H., Zhang D., Fang Y. R., Xiao X., Li M.*, Lv L. X.*, Chang H.*. (2021). Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. Neuropsychopharmacology, 46(6), 1103-1112.

其他代表性论文/专著：

(1)  Yang Z. H.^#, Cai X.^#, Qu N.^#, Zhao L. J., Zhong B. L., Zhang S. F., Chen J., Xia B., Jiang H. Y., Zhou D. Y., Liu W. P., Chang H., Xiao X., Li Y.*, Li M.*. (2020). Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32. Zoological Research, 41(1), 84-89.

(2)  Liu W. P.,^# Li W. Q.,^# Cai X.,^# Yang Z. H.,^# Li H. J., Su X., Song M., Zhou D. S., Li X. X., Zhang C., Shao M. L., Zhang L. W., Yang Y. F., Zhang Y., Zhao J. Y., Chang H., Yao Y. G., Fang Y. R., Lv L. X.*, Li M.*, Xiao X.*. (2020). Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci. Neuropsychopharmacology, 45(7), 1196-1206.

(3)  Liu W. P.^#, Yan H.^#, Zhou D. Y.^#, Cai X.^#, Zhang Y. Y. N., Li S. Y., Li H. J., Li S. W., Zhou D. S., Li X. X., Zhang C., Sun Y., Dai J. P., Zhong J. M., Yao Y. G., Luo X. J., Fang Y. R. , Zhang D., Ma Y. N., Yue W. H.*, Li M.*, Xiao X.*. (2019). The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population. Translational Psychiatry, 9(1), 333.

(4)  Li H. J.^#, Qu N.^#, Hui L.^#, Cai X., Zhang C. Y., Zhong B. L., Zhang S. F., Chen J., Xia B., Wang L., Jia Q. F., Li W., Chang H., Xiao X.*, Li M.*, & Li Y.*. (2020). Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data. Translational Psychiatry, 10(1), 98.

(5)  Yang Z. H.^#, Zhou D. Y.^#, Li H. J.^#, Cai X., Liu W. P., Wang L., Chang H., Li M.*, Xiao X.*. (2020). The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine. Molecular Psychiatry, 25(1), 48-66.