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PNAS:感染与免疫中共同的分子武器---宿主产生细菌毒素样蛋白清除微生物感染
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| 天然免疫是机体的第一道防线，在抵御和清除病原微生物侵害中担负着至关重要的作用,但目前人们对宿主激发和调节迅速而可控的天然免疫响应的生物策略和分子途径并不完全了解。病原微生物感染机体依赖其毒力因子，其中孔道形成毒素( pore-forming toxins )是最大的一类由致病菌产生的蛋白毒力因子，其能插入细胞膜形成通道而引起细胞损伤,如产气单胞菌溶素... |
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